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How do GLP-1/GIP medications work?

You come home from work after a long day, and you end up scarfing down your dinner. Twenty minutes later you start feeling that all too familiar feeling that you overdid it. The most common cause of weight gain is that we do not allow enough time for our stomach to send the signal to our brain that we have eaten enough. Unfortunately, we likely had one slice of pizza or a burger too many before that delayed signal kicks in and tells us we have eaten enough food.

What medications such as Semaglutide (Ozempic® / Wegovy®) & Tirzepatide (Mounjaro® / Zepbound®) do is gives us a boost of the hormone that tells us that we have eaten enough to satisfy our hunger. So instead of inhaling three slices of pizza, your are going to feel that disinterest in another bite, perhaps even midway through that very first slice! It also works by delaying gastric emptying, which causes us to feel full for longer. So those cravings for a snack between meals are eliminated. This combo of feeling satiated quickly and feeling full for longer, results in amazing weight loss. Essentially, it resolves the most difficult part of dieting, which is appetite and hunger control. No more of that constant thought of your next meal, or that struggle not to have a second helping, or even that continuous battle against your food cravings.

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Side Effects & Long-term Goals

We discussed earlier the basic principles of how the medication works. It is that very mechanism of action (delayed gastric emptying, increased satiety hormone) that may cause side effects in some people. Since it works on the gut, constipation, bloating, nausea, vomiting, flatulence may occur (amongst other possible side effects). We found in practice, as well as in FDA trials, that Tirzepatide (Mounjaro® / Zepbound®) had much less side effects and had better weight loss, compared to Semaglutide (Ozempic® / Wegovy®) and it is why we primarily offer Tirzepatide in our program. The vast majority of patients report little-to-no side effects from Tirzepatide.

Most people can expect to lose around 20% of their body weight in the first year, most of which comes off in the first few months. Though we prefer a steady 5-10lbs of weight loss a month, its not uncommon to lose 10-20lbs the first month or two especially if you are putting in the added effort of exercise/weight training (highly recommended).

No one wants to be on medication all their life, especially when its not cheap. Here at Sky Health we want to provide you with the tools and the boost you need to start your health/weight loss journey. We want you retrain your body and mind of what is appropriate food intake and even methods of allowing your natural hormone to take effect. Once you re-learn what your body actually needs for nutrition, and can overcome the food noise, you are on your way to a medication free, healthier, happier you!

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High-Protein Diet Plan for
Optimal Health & Muscle Maintenance

A high-protein diet can help support muscle maintenance, promote fat loss, and keep you feeling full longer. Below is a sample 7-day meal plan focused on higher protein intake while maintaining a balance of healthy fats and carbohydrates.

Key Guidelines:

  • Daily Protein Goal: 30-40% of your daily caloric intake

  • Carbohydrates: 30-40% of your intake from whole grains, fruits, and vegetables

  • Fats: 20-30% of your intake from healthy fats like avocados, nuts, and olive oil

  • Hydration: Drink plenty of water throughout the day (3-4 liters)

Protein-Rich Food Options:

  • Animal Sources: Chicken breast, lean beef, turkey, fish (salmon, tuna, cod), eggs, shrimp

  • Plant-Based: Tofu, tempeh, lentils, chickpeas, quinoa, edamame

  • Dairy: Greek yogurt, cottage cheese, low-fat milk

  • Supplements: Whey protein, casein protein, plant-based protein powders

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Sample 7-Day High-Protein Diet Plan

Day 1:

Breakfast: Greek yogurt (200g) with mixed berries and 2 tablespoons of chia seeds (30g protein)

Snack: 1 boiled egg and a handful of almonds (15g protein)

Lunch: Grilled chicken salad with mixed greens, avocado, and olive oil dressing (35g protein)

Snack: Cottage cheese (100g) with cucumber slices (15g protein)

Dinner: Baked salmon (150g) with quinoa and steamed broccoli (40g protein)

Day 2:

Breakfast: Scrambled eggs (3 eggs) with spinach and feta cheese (25g protein)

Snack: Protein smoothie with whey protein (25g protein), banana, and almond milk (30g protein)

Lunch: Turkey breast (150g) with sweet potato and sautéed kale (35g protein)

Snack: Edamame (1 cup) with sea salt (17g protein)

Dinner: Grilled steak (150g) with asparagus and a side of brown rice (40g protein)

Day 3:

Breakfast: Protein pancakes made with eggs, oats, and protein powder (30g protein)

Snack: Hard-boiled eggs (2) with baby carrots (12g protein)

Lunch: Tuna salad (1 can tuna) with mixed greens and olive oil vinaigrette (30g protein)

Snack: Greek yogurt with sunflower seeds (20g protein)

Dinner: Grilled chicken breast (150g) with roasted vegetables and couscous (35g protein)

Day 4:

Breakfast: Omelette with 3 eggs, mushrooms, and lean turkey (30g protein)

Snack: Cottage cheese with pineapple chunks (15g protein)

Lunch: Shrimp stir-fry with mixed vegetables and brown rice (35g protein)

Snack: Protein bar (20g protein)

Dinner: Baked cod (150g) with sweet potato and spinach (35g protein)

Day 5:

Breakfast: Smoothie bowl with protein powder, almond butter, and mixed fruits (30g protein)

Snack: 1 boiled egg and a handful of walnuts (12g protein)

Lunch: Grilled turkey burger (150g) with avocado and side salad (35g protein)

Snack: Hummus (50g) with cucumber sticks (10g protein)

Dinner: Grilled tofu (200g) with quinoa and roasted Brussels sprouts (30g protein)

Day 6:

Breakfast: Scrambled eggs with turkey sausage and sautéed spinach (30g protein)

Snack: Greek yogurt with chia seeds and raspberries (20g protein)

Lunch: Chicken and vegetable stir-fry with cauliflower rice (40g protein)

Snack: Protein shake with almond milk (25g protein)

Dinner: Baked cod (150g) with roasted sweet potato and steamed broccoli (35g protein)

Day 7:

Breakfast: Egg white omelette with avocado and salsa (25g protein)

Snack: Cottage cheese with mixed nuts (20g protein)

Lunch: Grilled beef kebabs with mixed vegetables and hummus (35g protein)

Snack: Protein bar (20g protein)

Dinner: Grilled lamb (150g) with roasted vegetables and couscous (40g protein)

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The Principles of Weight Loss:
A Comprehensive Guide to Achieving Sustainable Results

Weight loss is a journey that involves more than just eating less and exercising more. To achieve sustainable and healthy results, it’s important to understand the underlying principles that govern how our bodies lose weight. In this blog post, we will break down these key principles and explain how you can apply them to your own health journey.

1. Caloric Deficit: The Foundation of Weight Loss

At its core, weight loss happens when you burn more calories than you consume, creating a caloric deficit. Calories are the energy we get from food, and if you eat more than your body needs, the excess is stored as fat. On the other hand, when you eat fewer calories than your body requires, it taps into stored fat for energy, resulting in weight loss.

To achieve a caloric deficit:

  • Track your intake: Use apps or food journals to monitor what you eat and ensure you stay within your calorie goals.

  • Increase activity: Exercising more burns additional calories, helping you reach a deficit without severely restricting food intake.

2. Macronutrient Balance: Focus on Protein, Fats, and Carbs

While calories are essential, the types of calories you consume matter too. The three macronutrients—protein, fats, and carbohydrates—all play different roles in the body and affect weight loss differently.

  • Protein: Essential for building and maintaining muscle, protein also helps increase satiety, meaning it keeps you feeling full longer. Eating a higher protein diet can help preserve muscle mass during weight loss, which is important for maintaining a healthy metabolism.

  • Fats: Healthy fats (found in foods like avocados, nuts, and olive oil) support hormone function, protect organs, and help absorb vitamins. While fats are more calorie-dense than protein and carbs, they are essential in a balanced diet.

  • Carbohydrates: Carbs provide quick energy. However, prioritizing complex carbs like whole grains, fruits, and vegetables, which are high in fiber, can help stabilize blood sugar levels and keep you feeling fuller for longer.

The key is finding a balance of these macronutrients that fuels your body, keeps you satisfied, and supports your overall goals.

3. Exercise: Building Muscle and Boosting Metabolism

While diet is crucial for weight loss, exercise plays an equally important role. Physical activity helps:

  • Burn more calories: Engaging in regular cardio and strength training increases the number of calories you burn, helping you create a larger caloric deficit.

  • Build muscle: Resistance training, such as lifting weights, not only helps burn calories during the workout but also promotes muscle growth. Muscle is metabolically active tissue, meaning it burns more calories even when you're at rest.

A combination of strength training and cardiovascular exercise (such as walking, running, swimming, or cycling) will help you maximize fat loss and maintain or build muscle.

4. Mindful Eating: Control Portions and Emotional Eating

One often-overlooked aspect of weight loss is mindful eating. It’s easy to eat more than we realize, especially when distracted or using food as a way to cope with emotions. Mindful eating involves paying attention to hunger cues, eating slowly, and being aware of what and how much you're consuming.

Tips for mindful eating:

  • Eat without distractions: Avoid watching TV or scrolling on your phone while eating, so you can focus on your food and recognize when you’re full.

  • Use smaller plates: This can help control portion sizes and prevent overeating.

  • Address emotional eating: Find alternative ways to cope with stress or emotions, such as exercising, journaling, or talking to a friend.

5. Consistency Over Perfection

One of the most important principles of weight loss is consistency. Weight loss isn’t about being perfect with your diet and exercise every day—it’s about making steady, sustainable changes over time. If you slip up, don’t get discouraged. Get back on track the next day and continue moving forward.

Small, consistent changes often lead to better long-term results than extreme diets or workout plans that are hard to maintain. Focus on building habits that support your goals, such as cooking at home more often, staying active, and practicing mindful eating.

6. Rest and Recovery: The Role of Sleep

Sleep is often overlooked when it comes to weight loss, but it plays a vital role in regulating your hormones, especially those involved in hunger and satiety like ghrelin and leptin. Poor sleep can increase hunger, reduce feelings of fullness, and make it harder to resist high-calorie foods. Additionally, lack of sleep can impact your energy levels, making it more difficult to exercise and stay active.

To optimize your weight loss efforts, aim for 7-9 hours of quality sleep per night and incorporate rest days into your exercise routine to allow your body to recover.

7. Hydration: A Simple Yet Effective Tool

Drinking plenty of water is crucial for overall health, but it also has specific benefits for weight loss:

  • Boosts metabolism: Drinking water can temporarily increase your metabolic rate, helping you burn more calories.

  • Reduces hunger: Sometimes, the body can confuse thirst with hunger. Staying hydrated helps prevent unnecessary snacking and overeating.

  • Supports digestion: Proper hydration helps keep your digestive system functioning smoothly, which is important for overall metabolism and weight loss.

Aim to drink at least 8 cups (2 liters) of water a day, or more if you're physically active.

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